HUMAN CHALLENGE STUDIES
Typhoid Swallowers
TYPHOID SWALLOWERS
In 2017, about 100 participants in the City of Oxford, UK drank live typhoid bacteria to test how well a new vaccine worked. Here is the story of two of the trial volunteers.
(Credit: Interview by Samantha Vanderslott & Claas Kirchhelle. Filming by Gold Filling Records)
(Para)typhoid challenge trials in Oxford
We are working with the Oxford Vaccine Group to develop engagement materials about paratyphoid fever. In 2022 the University of Oxford in collaboration with the University of Maryland began a trial for a new paratyphoid vaccine in human volunteers in Oxford. Paratyphoid fever is a form of enteric fever similar to typhoid. In the first study of its kind, where vaccination participants will be ‘challenged’ with paratyphoid to see whether the vaccine can prevent infection. Using a human challenge trial will allow an understanding of the vaccine’s effectiveness without having to immunise thousands of people.
