(Para)typhoid challenge trials in Oxford

We are working with the Oxford Vaccine Group to develop engagement materials about paratyphoid fever. In 2022 the University of Oxford in collaboration with the University of Maryland began a trial for a new paratyphoid vaccine in human volunteers in Oxford. Paratyphoid fever is a form of enteric fever similar to typhoid. In the first study of its kind, where vaccination participants will be ‘challenged’ with paratyphoid to see whether the vaccine can prevent infection. Using a human challenge trial will allow an understanding of the vaccine’s effectiveness without having to immunise thousands of people.