(Para)typhoid challenge trials in Oxford
We are working with the Oxford Vaccine Group to develop engagement materials about paratyphoid fever. In 2022 the University of Oxford in collaboration with the University of Maryland began a trial for a new paratyphoid vaccine in human volunteers in Oxford. Paratyphoid fever is a form of enteric fever similar to typhoid. In the first study of its kind, where vaccination participants will be ‘challenged’ with paratyphoid to see whether the vaccine can prevent infection. Using a human challenge trial will allow an understanding of the vaccine’s effectiveness without having to immunise thousands of people.
'Typhoid Swallowers' Video
TYPHOID SWALLOWERS
In 2017, about 100 participants in the City of Oxford, UK drank live typhoid bacteria to test how well a new vaccine worked. Here is the story of two of the trial volunteers.
(Credit: Interview by Samantha Vanderslott & Claas Kirchhelle. Filming by Gold Filling Records)
‘How do vaccines work?’ Video
HOW DO VACCINES WORK?
To understand how vaccines work, it helps to learn how vaccines harness the natural activity of your immune system. This short animation made by the Oxford Vaccine Group explains how vaccines enable the body to make the right sort of antibodies to protect against a particular disease.
(Credit: Originally developed by Oxford Vaccine Group. Concept & script by Sarah Loving & Samantha Vanderslott. Design: Ben Leighton)
Oxford lab tour
Take a virtual tour of the laboratories at the Oxford Vaccine Group, Jenner Institute and Clinical Biomanufacturing Facility at the University of Oxford to see how vaccines are developed and tested. Look at the different rooms and equipment needed for scientific research.
Samantha Vanderslott/Claas Kirchhelle; Design: Matthew Evans/ 360 Virtual Tours.
